Current Issue : January-March Volume : 2025 Issue Number : 1 Articles : 3 Articles
The most critical among the many valuable tools that help in the furtherance of medical science and healthcare are the biochemical and pharmaceutical patents. Patents help to protect the fruits of creativity in form of new drugs, treatments and biotechnological processes by providing exclusive rights to the inventor for a certain period of time. The major role of such patents is to offer companies and researchers enough encouragement to continue investing in research and development for maximum safety and security of their intellectual property. The complete application involves proving newness, usefulness and non-obviousness to the invention and at approval, the patent office grants that patent after a proper inquiry. Major changes in the pharmaceutical and biotech field have been witnessed in particularly personalized and biologics that are heading towards a future where changes may be positive or negative for existing treatments of diseases. Indeed, in-silico models and assays have revised the aspects with innovative plants that can only make modest contribution to bio- and pharma-product development....
In the present study, bilayer gastroretentive delivery systems of clarithromycin with aloe vera were successfully developed in the form of hydrodynamically balanced tablets to improve the local action and ultimately its bioavailability. A. vera gel has mucoprotective effect and is also reported to have antiulcer activity. Considering these facts, for clarithromycin and A. vera, the objective of this project work was to design and develop a bilayer floating tablet of Clarithromycin and A. vera gel powder by a direct compression method for the treatment of peptic ulcer. The tablets were formulated using different grades of polymers (HPMC K4M, HPMC K15M and Chitosan) and effervescing agent (NaHCO3). During the formulation, Fourier-transform infrared spectroscopy (FTIR) analysis was performed for possible interactions between drugs and excipients. No interactions between drugs and excipients were noted. Moreover, the bilayer tablets’ thickness, diameter, friability, hardness, weight variation, dissolution and percent purity were found within the acceptable limits. Buoyancy lag time, total floating time, tablet density, Swelling studies showed satisfactory results for batch F1, F2, F3, F5, F6 and F8. The formulation F3 was evaluated for effect of hardness on floating lag time and the results showed that the floating lag time increased as hardness increased due to reduction in porosity. In-vitro dissolution of batch F3 containing HPMC K15M showed good drug release rate in comparison to remaining batches containing chitosan, HPMC K4M, HPMC K10M which were not able to sustain their release up to 10 hrs. Formulations subjected to curve fitting analysis showed to best fit Korsemeyer – Peppas equation and followed non-Fickinian diffusion mechanism. Comparison study with marketed product Clarithro ER showed that the optimized formulation F3 has better control over release rate in comparison with the marketed product....
Betahistine hydrochloride is an orally administered antihistaminic drug. It has a very strong affinity for histamine H3 receptors and a weak affinity for histamine H1 receptors. It has been used to control vertigo in patients of Meniere’s disease with half-life of 2-3 hrs. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of betahistine HCl were prepared by direct compression method using altered concentrations of HPMC K4, HPMC K15 and PVK30 as polymers. Then all the nine formulations were evaluated for uniformity of weight, hardness, thickness, friability test, floating lag time, drug content, dissolution studies and drug release studies. Compatibility studies was execution during FTIR shown that there was absence of probable chemical interaction between pure drug and excipients. The varying concentration of gas generating agent and polymers was found to effect on in-vitro drug release and floating lag time. In-vitro drug release of floating gastro retentive tablet of lovastatin shown that the formulation F6 was found to be the best formulation F6 as it showed less friability< 1, good hardness 4.9 kg/cm2, less floating lag time 2.5 (sec). The results indicated that optimizes formulation F6 on immersion in 0.1N HCl at 37±0.5°C tablets immediately and remain buoyant upto 12hr without disintegration. Thus, it can be concluded that prepared floating tablets of betahistine HCl may prove to be a potential candidate for safe and effective controlled drug delivery over an extended period of time for gastro retentive drug delivery system....
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